CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2798
Family Name Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00337968 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Motesanib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DKH f... 15 46
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Transient receptor potential cation channel subfamily V member... 3 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00337970 CHEMBL340156 Bioactive AGN-PC-075KX7
CFAMM00337969 CHEMBL434423 Bioactive AGN-PC-075KXA
CFAMM00337968 CHEMBL131182 Bioactive AGN-PC-075KV1
CFAMM00337971 CHEMBL130558 Bioactive AGN-PC-075KX0

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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