CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid family
No. of Seeds 9 No. of Other Members 46
Family Centroid CFAMM00309779 Functional Category Bioactive with Natural Product
Superfamily Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl cis-trans isomerase FKBP4 Binder Superfamily
Class Class 2689

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Muscarinic acetylcholine receptor Ligand Mebeverine Family 2 27
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Histamine H3 receptor Ligand A-349821 Family 49 228
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Peptidyl-prolyl cis-trans isomerase FKBP1A and Serine/threonin... 10 9
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor CHEMBL368... 1 2
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor CHEMBL437... 2 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor SureCN101... 2 6
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 5-[[3-[(2... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
Reverse transcriptase/RNaseH inhibitor AC1O5COS family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 1 0
Lysophosphatidic acid receptor 3 ligand [4-[(2R)-2-[[(Z)-octad... 1 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
(1R,5S)-3-(2-(3,4,5-trimethoxyphenyl)acetyl)-3,4,5,6-tetrahydr... 2 0
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


External ID

Functional Category

Molecule Name

CFAMM00309772 CHEMBL320478 Bioactive 2-[3-[(1R)-3-phenyl-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
CFAMM00309779 CHEMBL107101 Bioactive 2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
CFAMM00309801 CHEMBL54189 Bioactive 1,7-diphenylheptan-4-yl 1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
CFAMM00309793 CHEMBL277083 Bioactive 2-[3-[1-[(2S)-1-[(2S)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
CFAMM00309806 CHEMBL266848 Bioactive 2-[3-[3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)pentanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
CFAMM00309776 CHEMBL110674 Bioactive 1bl4
CFAMM00309781 CHEMBL277560 Bioactive 2-[3-[3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-3-methyl-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
CFAMM00309810 CHEMBL280262 Bioactive 2-[3-[3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
CFAMM00309774 CHEMBL279119 Bioactive 2-[3-[3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



26406 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543