CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2835
Family Name Dual specificity protein kinase CLK1 and Dual specificity protein kinase CLK4 inhibitor 4-(1,3-benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-2-amine family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00338402 Functional Category Bioactive
Superfamily Dual specificity protein kinase CLK1 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 10
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
Vascular endothelial growth factor receptor 2 and Serine/threo... 1 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Dihydrofolate reductase inhibitor 5-[[4-(2,4-dichlorophenyl)-6... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A1 ligand BAS 00727702 family 1 4
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase and cAMP-specific... 1 3
Neuropeptide S receptor ligand 5-(4-chlorophenyl)-6-methoxy-5-... 4 0
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-[(... 1 0
Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 1
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00338402 CHEMBL1898197 Bioactive 4-(1,3-benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-2-amine
CFAMM00338396 CHEMBL2392364 Bioactive 4-(1,3-benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]pyrimidin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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