CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28511
Family Name Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha inhibitor (2R)-2-amino-N-[3-benzoyl-4-(benzylsulfonylamino)phenyl]-3-sulfanylpropanamide;hydrochloride family
No. of Seeds 4 No. of Other Members 13
Family Centroid CFAMM00485817 Functional Category Bioactive
Superfamily Aurora kinase B Inhibitor Hesperadin Superfamily
Class Class 545

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Amonafide family 3 35
Intedanib family 7 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Aurora kinase B Inhibitor Hesperadin Family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Bifunctional epoxide hydrolase 2 inhibitor N-(3-carbamoyl-4-pi... 1 0
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0


External ID

Functional Category

Molecule Name

CFAMM00485824 CHEMBL431632 Bioactive (2R)-2-amino-N-[3-benzoyl-4-[(2,2-diphenylacetyl)amino]phenyl]-3-sulfanylpropanamide;hydrochloride
CFAMM00485819 CHEMBL99922 Bioactive (2R)-2-amino-N-[3-benzoyl-4-[(4-methylphenyl)methylsulfonylamino]phenyl]-3-sulfanylpropanamide;hydrochloride
CFAMM00485828 CHEMBL95848 Bioactive (2R)-2-amino-N-[3-benzoyl-4-[[2-(4-bromophenyl)acetyl]amino]phenyl]-3-sulfanylpropanamide;hydrochloride
CFAMM00485817 CHEMBL95690 Bioactive (2R)-2-amino-N-[3-benzoyl-4-(benzylsulfonylamino)phenyl]-3-sulfanylpropanamide;hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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