CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28627
Family Name Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyphenyl)phenyl]methyl]-5-methyl-1,3-oxazolidin-2-one family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00486195 Functional Category Bioactive with Natural Product
Superfamily Nuclear receptor ROR-gamma and Ras-related protein Rab-9A Binder Superfamily 6
Class Class 51

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A4C Family 3 18
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BAX family 1 0
Putative NP ZINC04061066 Family 18 0
NP N-(4-chlorobenzyl)-n-(3-(4-isopropoxyphenyl)-3-phenylpropyl... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00486195 CHEMBL520639 Bioactive (5R)-3-[[4-(4-ethoxyphenyl)phenyl]methyl]-5-methyl-1,3-oxazolidin-2-one
CFAMM00486202 CHEMBL485528 Bioactive (5R)-3-[[4-(2-ethoxyphenyl)phenyl]methyl]-5-methyl-1,3-oxazolidin-2-one
CFAMM00486201 CHEMBL450207 Bioactive AGN-PC-0504IM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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