CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28669
Family Name Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-(4-methoxy-2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00486384 Functional Category Bioactive
Superfamily Beta-lactamase and Beta-2 adrenergic receptor Binder Superfamily
Class Class 1249

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1


External ID

Functional Category

Molecule Name

CFAMM00486384 CHEMBL458825 Bioactive 2-[1-[1-(4-methoxy-2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
CFAMM00486376 CHEMBL516175 Bioactive 2-[1-[1-[2-(difluoromethyl)-4-methoxyphenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
CFAMM00486382 CHEMBL504383 Bioactive 2-[1-[1-(6-methoxy-2-methylpyridin-3-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
CFAMM00486381 CHEMBL515843 Bioactive 2-[1-[1-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
CFAMM00486379 CHEMBL462789 Bioactive 2-[1-[1-(2-chloro-4-methoxyphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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