CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28672
Family Name Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 ligand benzimidazole scaffold, 7 family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00486390 Functional Category Bioactive
Superfamily cAMP and Tyrosine-protein kinase SYK Binder Superfamily
Class Class 3568

Cousin Family NamesSeedsMembers
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cytochrome P450 3A4 and Insulin-like growth factor 1 receptor ... 24 57
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Insulin-like growth factor 1 receptor ligand (3E)-4-[2-(4-brom... 5 13


External ID

Functional Category

Molecule Name

CFAMM00486392 CHEMBL460996 Bioactive benzimidazole scaffold, 8
CFAMM00486391 CHEMBL460997 Bioactive benzimidazole scaffold, 9
CFAMM00486390 CHEMBL461422 Bioactive benzimidazole scaffold, 7

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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