CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2869
Family Name Insulin-like growth factor-binding protein 4 and Insulin-like growth factor-binding protein 2 inhibitor NBI-31772 family
No. of Seeds 4 No. of Other Members 44
Family Centroid CFAMM00338773 Functional Category Bioactive with Human Metabolite
Superfamily Prelamin-A/C and Cyclin-dependent kinase 5 Binder Superfamily
Class Class 2976

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand Talnetant Family 3 49
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Prostaglandin E2 receptor EP1 subtype Ligand GSK-345931A Family 5 14
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Prelamin-A/C and Bloom syndrome protein inhibitor 7-Chlorokynu... 1 10
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 0
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 1 0
NP 8-hydroxyquinoline-2-carbaldehyde Family 1 0


External ID

Functional Category

Molecule Name

CFAMM00338763 CHEMBL130994 Bioactive 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-2H-isoquinolin-3-one
CFAMM00338742 CHEMBL58396 Bioactive 1-[(3,4-dihydroxyphenyl)methyl]-7-hydroxy-6-oxo-2H-isoquinoline-3-carboxylic acid
CFAMM00338768 CHEMBL56978 Bioactive 4-[(3,4-dihydroxyphenyl)methyl]-6-hydroxy-7-oxo-1H-quinoline-2-carboxylic acid
CFAMM00338773 CHEMBL292700 Bioactive NBI-31772

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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