CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28716
Family Name Beta-2 adrenergic receptor and Beta-3 adrenergic receptor ligand 2-(1-benzylimidazol-2-yl)-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]acetamide family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00486535 Functional Category Bioactive
Superfamily Beta-2 adrenergic receptor and Histamine H3 receptor Binder Superfamily
Class Class 3281

Cousin Family NamesSeedsMembers
14-alpha sterol demethylase Inhibitor Terconazole Family 4 46
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(2-phenoxy-eth... 1 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Beta-1 adrenergic receptor ligand 1-[4-[2-(5-bromo-1H-imidazol... 3 8
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Rho-associated protein kinase 2 and RAC-alpha serine/threonine... 1 2
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 1 0
Heme oxygenase 1 inhibitor 1-[[(2R,4R)-2-[2-(4-chlorophenyl)et... 4 13


External ID

Functional Category

Molecule Name

CFAMM00486544 CHEMBL467102 Bioactive 2-[1-[(4-bromophenyl)methyl]imidazol-2-yl]-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]acetamide
CFAMM00486543 CHEMBL467103 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-2-[1-(naphthalen-2-ylmethyl)imidazol-2-yl]acetamide
CFAMM00486535 CHEMBL466088 Bioactive 2-(1-benzylimidazol-2-yl)-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]acetamide
CFAMM00486542 CHEMBL467502 Bioactive 2-[1-[(4-chlorophenyl)methyl]imidazol-2-yl]-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]acetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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