CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2872
Family Name Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family
No. of Seeds 5 No. of Other Members 33
Family Centroid CFAMM00327295 Functional Category Bioactive
Superfamily Cysteinyl leukotriene receptor 1 and B2 bradykinin receptor Binder Superfamily
Class Class 1637

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Leukotriene B4 receptor 1 Ligand SB-209247 Family 7 24
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
High affinity nerve growth factor receptor and Mitogen-activat... 2 7
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Renin Inhibitor CP-305202 Family 9 30
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
B2 bradykinin receptor ligand (E)-N-[2-[2,4-dimethoxy-N-methyl... 3 2
B2 bradykinin receptor ligand 2-(4-aminobutylcarbamoylamino)-N... 5 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Insulin-like growth factor-binding protein 4 and Insulin-like ... 4 44
B2 bradykinin receptor ligand 4-[(E)-3-[[2-[2,4-dichloro-3-[[4... 29 2
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cysteinyl leukotriene receptor 1 ligand 3-[1-[3-[(7-chloroquin... 5 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
Cysteinyl leukotriene receptor 1 ligand 7-[[3-(quinolin-2-ylme... 7 5
NS5B protein inhibitor AC1O5AET family 3 1
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-met... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-[2-... 7 1
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Caspase-1 inhibitor (3S)-3-[[2-[3-(naphthalene-2-carbonylamino... 1 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Type-1 angiotensin II receptor ligand 2-[(2-methyl-5,6,7,8-tet... 5 0
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Cysteinyl leukotriene receptor 1 ligand 6-bromo-4-oxo-3-(quino... 3 1
Proline--tRNA ligase, cytoplasmic inhibitor AC1NQN4X family 1 0
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1
Proteinase-activated receptor 1 ligand 2-[2-[(E)-2-[(3R,3aS,4S... 1 2
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
3-quinolin-2-ylchromen-2-one NP ZINC08690002 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00338803 CHEMBL131611 Bioactive AGN-PC-075KEA
CFAMM00338822 CHEMBL132167 Bioactive AGN-PC-075K9A
CFAMM00338808 CHEMBL336298 Bioactive SureCN8735687
CFAMM00338821 CHEMBL132162 Bioactive SureCN7810751

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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