CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM28724
Family Name Neuropeptide Y receptor type 5 and Thioredoxin glutathione reductase ligand 9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one family
No. of Seeds 13 No. of Other Members 6
Family Centroid CFAMM00486565 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 5 and Thioredoxin glutathione reductase Binder Superfamily
Class Class 2225

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Acetylcholinesterase Inhibitor Territrem B Family 3 21
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Neuropeptide Y receptor type 5 ligand 6-bromo-9-(2-hydroxy-4,4... 1 0
Neuropeptide Y receptor type 5 ligand AC1MJ6B5 family 2 0
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00486574 CHEMBL468846 Bioactive 9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-6-methoxy-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one
CFAMM00486567 CHEMBL466756 Bioactive AGN-PC-04UIBO
CFAMM00486581 CHEMBL468225 Bioactive AGN-PC-04UI7I
CFAMM00486579 CHEMBL469173 Bioactive AGN-PC-04UI7E
CFAMM00486572 CHEMBL512090 Bioactive ST037564
CFAMM00486565 CHEMBL491762 Bioactive 9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one
CFAMM00486578 CHEMBL469257 Bioactive AGN-PC-04UIBN
CFAMM00486571 CHEMBL508770 Bioactive (9S)-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one
CFAMM00486584 CHEMBL512996 Bioactive AGN-PC-077KK9
CFAMM00486576 CHEMBL469256 Bioactive AGN-PC-04UI39
CFAMM00486569 CHEMBL469041 Bioactive AGN-PC-04UI7H
CFAMM00486582 CHEMBL513701 Bioactive AGN-PC-04UI38
CFAMM00486568 CHEMBL467558 Bioactive 9-(6-hydroxy-8-oxospiro[3.5]non-6-en-7-yl)spiro[4,9-dihydro-2H-xanthene-3,1'-cyclobutane]-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48680 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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