CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2900
Family Name Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN5256502 family
No. of Seeds 8 No. of Other Members 8
Family Centroid CFAMM00339141 Functional Category Bioactive
Superfamily Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor Bosutinib Superfamily
Class Class 970

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Tivozanib family 4 6
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 10
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Sodium-dependent serotonin transporter and Alpha-2C adrenergic... 2 2
Transient receptor potential cation channel subfamily V member... 3 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Protein kinase C theta type inhibitor AGN-PC-04SQV8 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00339141 CHEMBL194352 Bioactive SureCN5256502
CFAMM00339146 CHEMBL425389 Bioactive SureCN5254234
CFAMM00339151 CHEMBL131245 Bioactive AC1NS5OJ
CFAMM00339144 CHEMBL197715 Bioactive SureCN5254106
CFAMM00339143 CHEMBL197713 Bioactive SureCN5253620
CFAMM00339149 CHEMBL337728 Bioactive SureCN5251276

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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