CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29140
Family Name Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-1H-pyridin-4-yl)-N-(3-pyrrolidin-1-ylpropyl)-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00487923 Functional Category Bioactive
Superfamily Coagulation factor X and Tyrosine-protein kinase ITK/TSK Binder Superfamily
Class Class 1365

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Intedanib family 7 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Transient receptor potential cation channel subfamily V member... 1 5
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
NP Methyl 2-(5,11-dioxo-2,3,11,11a-tetrahydro-1h-benzo[e]pyrro... 2 1
1,3,3a,5-tetrahydro-[1,3]thiazolo[4,3-c][1,4]benzodiazepine-4,... 3 1


External ID

Functional Category

Molecule Name

CFAMM00487923 CHEMBL549526 Bioactive 6-oxo-9-(2-oxo-1H-pyridin-4-yl)-N-(3-pyrrolidin-1-ylpropyl)-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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