CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM292
Family Name Pol polyprotein inhibitor (2R,3R,4R,5R)-3,4-dihydroxy-N-[(2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide family
No. of Seeds 22 No. of Other Members 10
Family Centroid CFAMM00309912 Functional Category Bioactive
Superfamily Pol polyprotein and Plasmepsin-1 Binder Superfamily
Class Class 3085

Cousin Family NamesSeedsMembers
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 40 29
Pol polyprotein inhibitor AC1LAK4B family 16 11
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,3,4-trihydroxy-N,N'-... 3 3
Pol polyprotein inhibitor AC1L9TSM family 1 0
Pol polyprotein inhibitor 2-[[(2R,3R,4R,5R)-6-[(1-carboxy-2-me... 5 2
Pol polyprotein inhibitor 3-[[(3S,5R)-5-benzyl-1-[(2S,4R)-4-be... 4 0
Pol polyprotein inhibitor (2R,4S)-5-[(5R)-3-[(3-aminophenyl)me... 4 2
Pol polyprotein inhibitor AC1LADII family 12 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 4
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5S)-3-hydroxy-5... 4 12
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,5-bis[(2-fluoropheny... 4 0
Plasmepsin-2 and Plasmepsin-1 inhibitor (2R,3R,4R,5R)-2,5-bis[... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00309919 CHEMBL422961 Bioactive (2R,3R,4R,5R)-2,5-bis[(2-fluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309899 CHEMBL107428 Bioactive (2R,3R,4R,5R)-2,5-bis[(4-fluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309912 CHEMBL264040 Bioactive (2R,3R,4R,5R)-3,4-dihydroxy-N-[(2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide
CFAMM00309918 CHEMBL356895 Bioactive (2R,3R,5R)-3-hydroxy-N-[(2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide
CFAMM00309905 CHEMBL431241 Bioactive (2R,3R,4R,5R)-2,5-bis[(2,5-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309898 CHEMBL358008 Bioactive 2-[[(2R,3R,4R,5R)-3,4-dihydroxy-6-[[(2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-2,5-bis(phenylmethoxy)hexanoyl]-methylamino]-3-methylbutanoic acid
CFAMM00309904 CHEMBL431422 Bioactive (2R,3R,4R,5R)-2,5-bis[(2,6-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309897 CHEMBL317031 Bioactive (2R,3R,4R,5R)-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide
CFAMM00309910 CHEMBL367562 Bioactive C2-symmetric compound 20
CFAMM00309903 CHEMBL322669 Bioactive (2R,3R,4R,5R)-2,5-bis[(2,4-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309916 CHEMBL358924 Bioactive (2R,3R,4R,5R)-N-benzyl-3,4-dihydroxy-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide
CFAMM00309922 CHEMBL431476 Bioactive (2R,3R,4R,5R)-3,4-dihydroxy-N-[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(phenylmethoxy)hexanediamide
CFAMM00309915 CHEMBL317690 Bioactive (2R,3R,4R,5R)-2,5-bis[(3,5-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309908 CHEMBL176888 Bioactive C2-symmetric compound 13
CFAMM00309921 CHEMBL319704 Bioactive (2R,3R,4R,5R)-2,5-bis[(2,3-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309914 CHEMBL369870 Bioactive C2-symmetric compound 11
CFAMM00309894 CHEMBL317236 Bioactive (2R,3R,4R,5R)-2,5-bis[(3,4-difluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
CFAMM00309907 CHEMBL367607 Bioactive C2-symmetric compound 19
CFAMM00309913 CHEMBL320936 Bioactive (2R,3R,4R,5R)-2,5-bis[(3-fluorophenyl)methoxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N'-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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