CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29271
Family Name TGF-beta receptor type-1 ligand SureCN373106 family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00488483 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 and Hepatocyte growth factor receptor Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Lethal factor Inhibitor GM6001 Family 50 435
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00488484 CHEMBL585117 Bioactive SureCN373482
CFAMM00488483 CHEMBL565645 Bioactive SureCN373106
CFAMM00488487 CHEMBL566439 Bioactive SureCN373629
CFAMM00488486 CHEMBL584928 Bioactive AGN-PC-07CRCI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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