CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29386
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform inhibitor SureCN4443661 family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00488885 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 3274

Cousin Family NamesSeedsMembers
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Family 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00488884 CHEMBL589142 Bioactive SureCN4441900
CFAMM00488883 CHEMBL591576 Bioactive AGN-PC-07NHIY
CFAMM00488881 CHEMBL583228 Bioactive AGN-PC-07NHHS
CFAMM00488879 CHEMBL604988 Bioactive SureCN4440302
CFAMM00488885 CHEMBL591338 Bioactive SureCN4443661

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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