CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29478
Family Name Glycine receptor subunit alpha-1 ligand [(1R,5R)-8-azabicyclo[3.2.1]octan-3-yl] pyridine-3-carboxylate family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00489191 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Dipeptidyl peptidase 2 Binder Superfamily
Class Class 2601

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Diacylglycerol O-acyltransferase 2 and Hydroxycarboxylic acid ... 4 45
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Cruzipain Inhibitor 2-(cycloheptylamino)-2-oxoethyl 2-aminonic... 1 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
5-hydroxytryptamine receptor 3A Ligand 3alpha-(1'-methyl-2'-in... 2 17
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Renin and Cytochrome P450 3A4 inhibitor (3R,3'S)-N-cyclopropyl... 3 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor et... 2 1
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 2
Transmembrane prolyl 4-hydroxylase inhibitor 2,2'-Bipyridine-5... 1 1
Putative NP ZINC18169450 Family 1 1
2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopen... 5 0
NP (2-methyl-5-(prop-1-en-2-yl)cyclopent-1-en-1-yl)methyl Ison... 2 0
6-pyridin-3-ylpyran-2-one NP 6-(pyridin-3-yl)-2h-pyran-2-one F... 1 2


External ID

Functional Category

Molecule Name

CFAMM00489195 CHEMBL608418 Bioactive [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] pyridine-3-carboxylate
CFAMM00489191 CHEMBL596237 Bioactive [(1R,5R)-8-azabicyclo[3.2.1]octan-3-yl] pyridine-3-carboxylate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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