CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29486
Family Name Vascular endothelial growth factor receptor 2 and Serine/threonine-protein kinase PLK1 ligand AGN-PC-07CK5S family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00489221 Functional Category Bioactive
Superfamily Aurora kinase A and Ephrin type-A receptor 3 Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
SB1518 family 7 103
MK-6096 family 3 69
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Transient receptor potential cation channel subfamily V member... 2 4
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Vascular endothelial growth factor receptor 2 and Serine/threo... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00489224 CHEMBL597393 Bioactive AGN-PC-07CK8D
CFAMM00489222 CHEMBL603463 Bioactive AGN-PC-014YRF
CFAMM00489221 CHEMBL598418 Bioactive AGN-PC-07CK5S
CFAMM00489219 CHEMBL597596 Bioactive AGN-PC-07CK8E

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22954 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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