CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM29556
Family Name Corticotropin-releasing factor receptor 1 ligand N-(dicyclopropylmethyl)-4-(2-fluoro-4,6-dimethoxyphenyl)-N-propylpyrimidin-2-amine family
No. of Seeds 3 No. of Other Members 35
Family Centroid CFAMM00489464 Functional Category Bioactive with Natural Product
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Transient receptor potential cation channel subfamily V member... 2 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Glucagon receptor ligand SureCN2647807 family 3 7
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Corticotropin-releasing factor receptor 1 ligand [6-[cycloprop... 1 2
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 2
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Transient receptor potential cation channel subfamily V member... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00489464 CHEMBL63457 Bioactive N-(dicyclopropylmethyl)-4-(2-fluoro-4,6-dimethoxyphenyl)-N-propylpyrimidin-2-amine
CFAMM00489462 CHEMBL61954 Bioactive AGN-PC-074E3N
CFAMM00489447 CHEMBL63989 Bioactive 4-(2-chloro-4,6-dimethoxyphenyl)-N-(dicyclopropylmethyl)-N-propylpyrimidin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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