CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2956
Family Name Prelamin-A/C inhibitor CHEMBL1374443 family
No. of Seeds 1 No. of Other Members 6
Family Centroid CFAMM00339952 Functional Category Bioactive
Superfamily Substance-P receptor Ligand R 673 Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Nitric oxide synthase, endothelial Inhibitor Acclaim Family 2 15
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Substance-P receptor Ligand R 673 Family 2 127
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Chymase Inhibitor Y-40613 Family 11 56
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Arachidonate 5-lipoxygenase Inhibitor 5-chloro-n-phenylbenzo[d... 3 15
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
5-hydroxytryptamine receptor 3A and Potassium voltage-gated ch... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 3
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 11 0
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Prostaglandin E synthase inhibitor 1-[5-chloro-6-(4-fluorophen... 8 27
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-(2,3-d... 4 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
Sigma non-opioid intracellular receptor 1 ligand 2-[4-(4-cyclo... 2 5
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Neutrophil elastase inhibitor 1-[4-(1,3-benzoxazol-2-ylsulfany... 3 0
Neuropeptide Y receptor type 5 ligand AGN-PC-07CNPD family 1 0
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-dichloro-1,3-... 1 5
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-difluoro-1,3-... 3 1
Diacylglycerol O-acyltransferase 1 inhibitor N-(3-oxo-1-propyl... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 1-(1-... 4 6
Potassium voltage-gated channel subfamily H member 2 and ATP-s... 1 0
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand Lodi... 1 0
Reverse transcriptase/RNaseH inhibitor 3-[2-(1-benzofuran-2-yl... 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6
Reverse transcriptase/RNaseH inhibitor 3-(1,3-benzoxazol-2-ylm... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26820 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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