CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2982
Family Name Reverse transcriptase/RNaseH inhibitor 1-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl]-3-(5-chloropyridin-2-yl)urea family
No. of Seeds 7 No. of Other Members 5
Family Centroid CFAMM00340254 Functional Category Bioactive
Superfamily Reverse transcriptase/RNaseH and Huntingtin Binder Superfamily
Class Class 873

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor PT-115 Family 7 19
Reverse transcriptase/RNaseH inhibitor AGN-PC-033LKQ family 1 0
Reverse transcriptase/RNaseH inhibitor AC1MHDM5 family 2 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Reverse transcriptase/RNaseH inhibitor 1-(5-chloropyridin-2-yl... 3 0


External ID

Functional Category

Molecule Name

CFAMM00340248 CHEMBL38318 Bioactive 1-[(1R,2R)-2-(2-chloro-3-ethoxy-6-fluorophenyl)cyclopropyl]-3-(5-cyanopyridin-2-yl)urea
CFAMM00340247 CHEMBL37835 Bioactive 1-[(1R,2R)-2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl]-3-(5-chloropyridin-2-yl)urea
CFAMM00340254 CHEMBL131643 Bioactive 1-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl]-3-(5-chloropyridin-2-yl)urea
CFAMM00340251 CHEMBL37024 Bioactive 1-(5-chloropyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2,6-difluorophenyl)cyclopropyl]urea
CFAMM00340244 CHEMBL340047 Bioactive urea-PETT deriv. 10
CFAMM00340253 CHEMBL133658 Bioactive 1-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl]-3-(5-cyanopyridin-2-yl)urea
CFAMM00340252 CHEMBL541204 Bioactive 1-(5-chloropyridin-2-yl)-3-[2-(3-ethoxy-2,6-difluorophenyl)cyclopropyl]urea

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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