CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2992
Family Name Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphenyl)-2-[(3-oxo-1H-2-benzofuran-5-yl)amino]propanoyl]amino]ethoxy]methyl]benzoic acid family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00340526 Functional Category Bioactive with Natural Product
Superfamily Cathepsin B and Menin Binder Superfamily
Class Class 257

Cousin Family NamesSeedsMembers
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Cathepsin B and Cathepsin L1 inhibitor 3-[[(2R)-2-cyano-2-[[(2... 3 4
Glucocorticoid receptor ligand 3,3,3-trifluoro-2-hydroxy-N-(4-... 22 3
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 2 9
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Cathepsin B and Cathepsin L1 inhibitor 5-[[(2R)-2-[[(2S)-2-ani... 1 0
Cathepsin B and Cathepsin L1 inhibitor SureCN14345745 family 2 0
Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphe... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00340532 CHEMBL133728 Bioactive 3-[[(2R)-2-cyano-2-[[(2S)-2-[(2-methyl-1,3-dioxoisoindol-5-yl)amino]-3-(3-methylphenyl)propanoyl]amino]ethoxy]methyl]benzoic acid
CFAMM00340531 CHEMBL131732 Bioactive 3-[[(2R)-2-cyano-2-[[(2S)-2-[(1,1-dimethyl-3-oxo-2-benzofuran-5-yl)amino]-3-(3-methylphenyl)propanoyl]amino]ethoxy]methyl]benzoic acid
CFAMM00340537 CHEMBL437251 Bioactive 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphenyl)-2-[(3-oxo-1,2-dihydroinden-5-yl)amino]propanoyl]amino]ethoxy]methyl]benzoic acid
CFAMM00340529 CHEMBL131688 Bioactive 5-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphenyl)-2-[(3-oxo-1H-2-benzofuran-5-yl)amino]propanoyl]amino]ethoxy]methyl]-2-fluorobenzoic acid
CFAMM00340526 CHEMBL336539 Bioactive 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphenyl)-2-[(3-oxo-1H-2-benzofuran-5-yl)amino]propanoyl]amino]ethoxy]methyl]benzoic acid
CFAMM00340525 CHEMBL335407 Bioactive 3-[[(2R)-2-cyano-2-[[(2S)-2-[(2-methyl-3-oxo-1H-isoindol-5-yl)amino]-3-(3-methylphenyl)propanoyl]amino]ethoxy]methyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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