CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2997
Family Name Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-amino-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylpentanamide family
No. of Seeds 8 No. of Other Members 11
Family Centroid CFAMM00342116 Functional Category Bioactive
Superfamily Prelamin-A/C and Retinal dehydrogenase 1 Binder Superfamily 4
Class Class 3234

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
Aurora kinase A inhibitor AGN-PC-0A9UUA family 4 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-hyd... 22 5
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Mitogen-activated protein kinase 14 inhibitor 1-(5-tert-butyl-... 2 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-09QXA7 fa... 16 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Tyrosine-protein kinase JAK2 and Cytochrome P450 3A4 inhibitor... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Aurora kinase A inhibitor SureCN2205392 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00342127 CHEMBL60962 Bioactive 2-[4-(methylamino)-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl]sulfanylhexanamide
CFAMM00342117 CHEMBL133103 Bioactive 2-(4-amino-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylbutanamide
CFAMM00342116 CHEMBL131702 Bioactive 2-(4-amino-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylpentanamide
CFAMM00342123 CHEMBL133605 Bioactive 2-(4-amino-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylhexanamide
CFAMM00342133 CHEMBL132909 Bioactive 2-(4-methylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylhexanamide
CFAMM00342122 CHEMBL133741 Bioactive 2-(4-methylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylbutanamide
CFAMM00342109 CHEMBL338723 Bioactive 2-(4-methylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl)sulfanylpentanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27291 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543