CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2999
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6412773 family
No. of Seeds 8 No. of Other Members 12
Family Centroid CFAMM00342190 Functional Category Bioactive with Natural Product
Superfamily Dual specificity protein kinase CLK4 and cAMP Binder Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Nitric oxide synthase, inducible inhibitor SureCN6943121 family 6 4
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Transient receptor potential cation channel subfamily V member... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00342176 CHEMBL336815 Bioactive 3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00342183 CHEMBL355574 Bioactive SureCN6407022
CFAMM00342190 CHEMBL131718 Bioactive SureCN6412773
CFAMM00342181 CHEMBL336291 Bioactive 3-(2,3-dihydro-1H-inden-5-yl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00342173 CHEMBL131892 Bioactive 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00342188 CHEMBL1744059 Bioactive (3R)-3-(1,3-benzodioxol-5-yl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00342178 CHEMBL177348 Bioactive SureCN6412972
CFAMM00342187 CHEMBL341092 Bioactive SureCN6412812

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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