CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM30
Family Name Adenosine kinase inhibitor GP683 family
No. of Seeds 12 No. of Other Members 7
Family Centroid CFAMM00306139 Functional Category Bioactive
Superfamily NEDD8-activating enzyme E1 catalytic subunit Inhibitor MLN4924 Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Pigment epithelium-derived factor Inhibitor Adpedr Family 2 112
Adenosine receptor A3 Ligand CF101 Family 24 560
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine kinase inhibitor abt-702 family 14 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3S,... 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A3 ligand (2R,3R,4S)-2-[6-[(3-bromophenyl)m... 3 0
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Adenosine receptor A2a and Adenosine receptor A2b ligand Cgs-2... 1 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Adenosine receptor A1 ligand (2,5-dioxopyrrolidin-1-yl) 2-[4-[... 3 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Adenosine receptor A2a and Adenosine receptor A3 ligand SureCN... 4 3
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306127 CHEMBL99829 Bioactive SureCN8326917
CFAMM00306139 CHEMBL100421 Bioactive GP683
CFAMM00306132 CHEMBL98867 Bioactive (2R,3R,4S,5R)-2-(4-anilino-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(azidomethyl)oxolane-3,4-diol
CFAMM00306125 CHEMBL380998 Bioactive (2R,3R,4R)-2-[5-(3-aminophenyl)-4-(4-fluoroanilino)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol
CFAMM00306131 CHEMBL328826 Bioactive (2R,3R,4S,5R)-2-(4-anilino-6-bromo-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
CFAMM00306124 CHEMBL436598 Bioactive SureCN8608954
CFAMM00306137 CHEMBL66277 Bioactive SureCN2035311
CFAMM00306136 CHEMBL318929 Bioactive (2R,3S,4R,5R)-2-methyl-5-[4-(4-methylanilino)-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol
CFAMM00306142 CHEMBL197801 Bioactive SureCN6881663
CFAMM00306135 CHEMBL194294 Bioactive (5R,6R,7S)-5-[4-(4-fluoroanilino)-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-4-oxaspiro[2.4]heptane-6,7-diol
CFAMM00306128 CHEMBL381682 Bioactive (2R,3R,4R)-2-[4-(4-bromoanilino)-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol
CFAMM00306141 CHEMBL373218 Bioactive SureCN6880334

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46158 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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