CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM30003
Family Name Retinal dehydrogenase 1 and Microtubule-associated protein tau inhibitor 4-(4-methylphenyl)-2-[(4-methylphenyl)sulfanyl]-4-oxobutanoic acid family
No. of Seeds 1 No. of Other Members 7
Family Centroid CFAMM00490578 Functional Category Bioactive
Superfamily Hydroxyacid oxidase 1 and Retinal dehydrogenase 1 Binder Superfamily
Class Class 1269

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Prostaglandin G/H synthase 1 Inhibitor Suprofen Family 4 52
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
CPI-613 family 4 35
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(p... 3 54
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-phe... 6 23
Prostaglandin G/H synthase 1 Inhibitor 2-(3'-ethylsulfanyl-bip... 1 4
Retinoic acid receptor gamma and Retinoic acid receptor beta l... 2 11
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 2 16
Hydroxyacid oxidase 1 inhibitor 4-[4-(4-methylsulfanylphenyl)p... 2 1
Flap endonuclease 1 and DNA repair protein complementing XP-G ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00490578 CHEMBL1085065 Bioactive 4-(4-methylphenyl)-2-[(4-methylphenyl)sulfanyl]-4-oxobutanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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