CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM30256
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand AGN-PC-0A8LWK family
No. of Seeds 2 No. of Other Members 48
Family Centroid CFAMM00491282 Functional Category Bioactive with Human Metabolite & Natural Product
Superfamily GABA theta subunit and Nonstructural protein 1 Binder Superfamily
Class Class 78

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Yohimbine Family 7 52
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Prostaglandin G/H synthase 2 Inhibitor Carprofen Family 1 5
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Brovincamine Fumarate family 2 2
Melanin-concentrating hormone receptor 1 Ligand Amg 076 Family 2 8
Toll-like receptor 9 Ligand TLR9 Agonist Family 8 8
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Endothelin B receptor Ligand IRL-2500 Family 34 87
5-hydroxytryptamine receptor 3A Ligand 3alpha-(1'-methyl-2'-in... 2 17
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Somatostatin receptor type 5 ligand L-817,818 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 9 3
A disintegrin and metalloproteinase with thrombospondin motifs... 2 12
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2
(1S)-2-(2-chloroacetyl)-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]i... 2 0
Putative NP ZINC00186639 Family 12 0
NP 1-(3-nitrophenyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole... 20 1
NP (s,e)-methyl 4-(((1,4-dioxo-3,4,12,12a-tetrahydropyrazino[1... 12 0
1-thiophen-2-yl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-ca... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00491282 CHEMBL11901 Bioactive AGN-PC-0A8LWK
CFAMM00491274 CHEMBL1949727 Bioactive CHEMBL1949727

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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