CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM30451
Family Name Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3-benzoxazol-2-ylidene)but-2-enylidene]-2-methoxycyclohexa-2,5-dien-1-one family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00491920 Functional Category Bioactive with Natural Product
Superfamily Estrogen receptor and Estrogen receptor beta Binder Superfamily 17
Class Class 994

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Substance-P receptor Ligand R 673 Family 2 127
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-difluoro-1,3-... 3 1
Glucocorticoid receptor and Progesterone receptor ligand (8S,1... 2 0
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Reverse transcriptase/RNaseH inhibitor 3-(1,3-benzoxazol-2-ylm... 1 0
(E)-2-(1,3-benzoxazol-2-yl)-3-(6-chloro-4H-1,3-benzodioxin-8-y... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00491917 CHEMBL339596 Bioactive ethyl (2Z)-2-[(E,4E)-4-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)but-2-enylidene]-3H-1,3-benzoxazole-5-carboxylate
CFAMM00491910 CHEMBL340121 Bioactive (4E)-2-methoxy-4-[(E,4Z)-4-(5-methyl-3H-1,3-benzoxazol-2-ylidene)but-2-enylidene]cyclohexa-2,5-dien-1-one
CFAMM00491921 CHEMBL332082 Bioactive ethyl (2Z)-2-[(E,4E)-4-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)but-2-enylidene]-3H-1,3-benzoxazole-6-carboxylate
CFAMM00491914 CHEMBL124538 Bioactive (4E)-4-[(E,4Z)-4-(5-chloro-3H-1,3-benzoxazol-2-ylidene)but-2-enylidene]-2-methoxycyclohexa-2,5-dien-1-one
CFAMM00491920 CHEMBL125074 Bioactive (4E)-4-[(E,4Z)-4-(3H-1,3-benzoxazol-2-ylidene)but-2-enylidene]-2-methoxycyclohexa-2,5-dien-1-one
CFAMM00491913 CHEMBL125151 Bioactive (4E)-4-[(E,4Z)-4-[6-(hydroxymethyl)-3H-1,3-benzoxazol-2-ylidene]but-2-enylidene]-2-methoxycyclohexa-2,5-dien-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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