CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM31337
Family Name DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrogenase 1 inhibitor CHEMBL1311989 family
No. of Seeds 1 No. of Other Members 18
Family Centroid CFAMM00494017 Functional Category Bioactive with Natural Product
Superfamily DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrogenase 1 inhibitor CHEMBL1311989 Superfamily
Class Class 5465

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Neutrophil elastase Inhibitor 3,4-dichloroisocoumarin Family 1 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 19
Protein kinase C delta type and Protein kinase C beta type inh... 3 9
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 2 16
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4754... 2 17
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 1 2
Aromatase inhibitor [(8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo... 2 10
Integrase inhibitor AGN-PC-00QHSA family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Tyrosine-protein phosphatase non-receptor type 1 ligand AGN-PC... 1 1
[(1S,2S,5R)-2-hydroxy-2-methyl-5-prop-1-en-2-ylcyclohexyl] ben... 1 2
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
Putative NP ZINC00277961 Family 3 1
4-hydroxy-2-(4-methoxycarbonylphenyl)-4-methyl-6-oxocyclohexan... 15 2
3-(4-hydroxy-6-methyl-2-oxopyran-3-yl)-3H-2-benzofuran-1-one N... 2 2
carboxylate NP ZINC04026424 Family 3 7
(3R)-spiro[2-benzofuran-3,3'-4H-isochromene]-1,1'-dione NP (r)... 1 2
methylbenzoate NP 7-oxocyclohepta-1,3,5-trien-1-yl 3-methylben... 2 1
ethoxy-[6-[ethoxy(oxido)methylidene]-3,7-dioxo-1,5-dihydro-s-i... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00494014 CHEMBL395296 Bioactive 4-[1-(4-carboxyphenyl)-3-oxohydroisobenzofuranyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

67924 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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