CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM322
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 inhibitor AGN-PC-07ZYBE family
No. of Seeds 5 No. of Other Members 25
Family Centroid CFAMM00310254 Functional Category Bioactive
Superfamily Peroxisome proliferator-activated receptor gamma Ligand SB-213068 Superfamily
Class Class 678

Cousin Family NamesSeedsMembers
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 4 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FVE ... 3 2
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Prostaglandin E synthase inhibitor 1-[5-chloro-6-(4-fluorophen... 8 27
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
Cholesteryl ester transfer protein inhibitor AGN-PC-09QM3I family 1 9
Cholesteryl ester transfer protein inhibitor SureCN2837741 family 6 1
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310233 CHEMBL1082022 Bioactive AGN-PC-07ZYBD
CFAMM00310262 CHEMBL1076700 Bioactive AGN-PC-07ZA2K
CFAMM00310254 CHEMBL1080159 Bioactive AGN-PC-07ZYBE
CFAMM00310232 CHEMBL1082023 Bioactive AGN-PC-07ZA2J

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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