CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3247
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2022213 family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00344809 Functional Category Bioactive with Natural Product
Superfamily DNA topoisomerase 1 and Thyroid hormone receptor beta Binder Superfamily
Class Class 2504

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-b... 3 6
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00344809 CHEMBL2022213 Bioactive CHEMBL2022213
CFAMM00344812 CHEMBL133285 Bioactive SureCN7019007

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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