CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3274
Family Name Adenosine receptor A3 ligand (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide family
No. of Seeds 30 No. of Other Members 54
Family Centroid CFAMM00345080 Functional Category Bioactive
Superfamily Adenosine receptor A3 and Adenosine receptor A1 Binder Superfamily 2
Class Class 3767

Cousin Family NamesSeedsMembers
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Adenosine receptor A3 and Adenosine receptor A1 ligand (1S,2R,... 32 9
Adenosine receptor A3 ligand 3-[2-[6-[(3-chlorophenyl)methylam... 1 0
Adenosine receptor A3 ligand (1R,2R,3S,4R,5S)-4-[2-[2-(2-chlor... 5 1
Adenosine receptor A3 and Adenosine receptor A1 ligand (1S,2R,... 6 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (1S,2R... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00345076 CHEMBL2368365 Bioactive (1R,2R,3S,4R,5S)-4-[6-[(4-amino-3-iodophenyl)methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345056 CHEMBL2064651 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(2-naphthalen-1-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345082 CHEMBL2064637 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(2-fluorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345121 CHEMBL2112162 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-[[3-(3-hydroxyprop-1-ynyl)phenyl]methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345062 CHEMBL257573 Bioactive (1S,2R,3S,4R,5S)-4-[6-[[3-[6-(2-acetamidoethylamino)-6-oxohex-1-ynyl]phenyl]methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345055 CHEMBL2064652 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(2-phenanthren-9-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345068 CHEMBL2064647 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(4-ethylphenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345087 CHEMBL256312 Bioactive (1S,2R,3S,4R,5S)-4-[6-[[3-[6-(2-aminoethylamino)-6-oxohex-1-ynyl]phenyl]methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345054 CHEMBL2064638 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(3-fluorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345067 CHEMBL2064646 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(3,5-difluorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345042 CHEMBL2402024 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(2-phenylethylamino)-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345080 CHEMBL2064635 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345093 CHEMBL583637 Bioactive (1R,2R,3S,4R,5S)-2,3-dihydroxy-4-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345106 CHEMBL2112163 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-[(2-phenylcyclopropyl)amino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345119 CHEMBL2368455 Bioactive (1R,2R,3S,4R,5S)-4-[6-[(3-bromophenyl)methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345073 CHEMBL2368366 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-(2,2-diphenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345112 CHEMBL2112158 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-[(2-methylphenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345066 CHEMBL2064645 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(3,4-difluorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345118 CHEMBL27376 Bioactive (1S,2R,3S,4R,5S)-4-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345072 CHEMBL2064649 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(4-acetylphenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345047 CHEMBL139417 Bioactive AGN-PC-075O7D
CFAMM00345065 CHEMBL2064644 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(3-aminophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345084 CHEMBL2064639 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(4-fluorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345110 CHEMBL2112155 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-[(3-fluorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345051 CHEMBL280580 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-4-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345123 CHEMBL2112160 Bioactive (1R,2R,3S,4R,5S)-4-[2-chloro-6-[(3-methylphenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345077 CHEMBL133387 Bioactive AGN-PC-075LHL
CFAMM00345057 CHEMBL2064650 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-[2-(4-phenylphenyl)ethynyl]purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345070 CHEMBL2064643 Bioactive (1S,2R,3S,4R,5S)-4-[2-[2-(4-bromophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
CFAMM00345083 CHEMBL2064636 Bioactive (1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(2-pyridin-2-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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