CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Beta-secretase 1 and Cathepsin D inhibitor 3ixj family
No. of Seeds 10 No. of Other Members 21
Family Centroid CFAMM00310346 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily
Class Class 3128

Cousin Family NamesSeedsMembers
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Beta-3 adrenergic receptor Ligand BMS-196085 Family 18 72
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Beta-secretase 1 and Cathepsin D inhibitor 3ixk family 2 9
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5224847 ... 3 24
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Beta-secretase 1 and Beta-secretase 2 inhibitor 3-(1,1-dioxoth... 6 2
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0


External ID

Functional Category

Molecule Name

CFAMM00310355 CHEMBL589771 Bioactive 3-N-[(2S,3S,5R)-6-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-1-(3,5-difluorophenoxy)-3-hydroxy-5-methoxy-6-oxohexan-2-yl]-5-[methyl(methylsulfonylmethyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
CFAMM00310341 CHEMBL591699 Bioactive 3-N-[(2S,3S,5R)-6-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-1-(3,5-difluorophenoxy)-5-ethoxy-3-hydroxy-6-oxohexan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
CFAMM00310360 CHEMBL591700 Bioactive 3-N-[(2S,3S,5R)-6-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-(cyclopropylmethoxy)-1-(3,5-difluorophenoxy)-3-hydroxy-6-oxohexan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
CFAMM00310346 CHEMBL573106 Bioactive 3ixj

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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