CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3306
Family Name Transient receptor potential cation channel subfamily V member 1 ligand 1-(7-hydroxynaphthalen-1-yl)-3-[[4-(trifluoromethoxy)phenyl]methyl]urea family
No. of Seeds 3 No. of Other Members 15
Family Centroid CFAMM00345391 Functional Category Bioactive
Superfamily Indoleamine 2,3-dioxygenase 1 and Insulin receptor Binder Superfamily
Class Class 2428

Cousin Family NamesSeedsMembers
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Transient receptor potential cation channel subfamily V member... 9 21
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Transient receptor potential cation channel subfamily V member... 6 1
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Transient receptor potential cation channel subfamily V member... 2 0
Transient receptor potential cation channel subfamily V member... 1 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Transient receptor potential cation channel subfamily V member... 1 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Melanin-concentrating hormone receptor 1 ligand 3-[4-fluoro-3-... 3 7
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 1 0
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00345403 CHEMBL251195 Bioactive 1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(7-hydroxynaphthalen-1-yl)urea
CFAMM00345391 CHEMBL147068 Bioactive 1-(7-hydroxynaphthalen-1-yl)-3-[[4-(trifluoromethoxy)phenyl]methyl]urea
CFAMM00345409 CHEMBL1779672 Bioactive AGN-PC-0A9QWL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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