CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM333
Family Name Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamoyloxy]-4,4-dimethyl-2-oxopyrrolidine-1-carboxylate family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00310397 Functional Category Bioactive with Natural Product
Superfamily Cathepsin K and Melanocortin receptor 4 Binder Superfamily
Class Class 1412

Cousin Family NamesSeedsMembers
Flovagatran family 12 546
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cruzipain Inhibitor WRR-204 Family 18 35
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin K inhibitor [(3S)-4,4-dimethyl-1-(naphthalene-2-carb... 4 9
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(phenylcarbam... 3 1
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Cathepsin K inhibitor [(3S)-1-(benzenesulfonyl)-4,4-dimethylpy... 2 0
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Pol polyprotein inhibitor AC1LADQG family 7 1
Cathepsin K and Cathepsin S inhibitor SureCN6197793 family 1 0
NS3 inhibitor SureCN14450642 family 4 7
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Protease inhibitor AC1O54RX family 2 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Mineralocorticoid receptor ligand (5R)-5-benzyl-N-[(3,5-dimeth... 5 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310399 CHEMBL1077003 Bioactive (4-phenylphenyl) (4S)-4-[[(3S)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamoyloxy]-3,3-dimethylpyrrolidine-1-carboxylate
CFAMM00310398 CHEMBL1077004 Bioactive (4-phenylphenyl)methyl (4S)-4-[[(3S)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamoyloxy]-3,3-dimethylpyrrolidine-1-carboxylate
CFAMM00310397 CHEMBL205517 Bioactive (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamoyloxy]-4,4-dimethyl-2-oxopyrrolidine-1-carboxylate
CFAMM00310401 CHEMBL436747 Bioactive (4-phenylphenyl)methyl (3S)-3-[[(3S)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamoyloxy]-4,4-dimethyl-2-oxopyrrolidine-1-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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