CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3345
Family Name Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]hex-4-ynoyl]amino]-3-hydroxy-6-methyl-N-(2-methylbutyl)heptanamide family
No. of Seeds 6 No. of Other Members 26
Family Centroid CFAMM00233233 Functional Category Bioactive
Superfamily Renin and Cathepsin D Binder Superfamily
Class Class 2047

Cousin Family NamesSeedsMembers
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Renin Inhibitor CP-80794 Family 16 112
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 2 2
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor penicillin deriv. 69 family 1 1
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Renin inhibitor [(2R)-1-[[(2S,3S,5R)-6-(butylamino)-1-cyclohex... 5 4
Neprilysin inhibitor SureCN489232 family 3 9
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3... 1 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Renin inhibitor N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-c... 4 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[... 3 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Renin inhibitor 2-methylpropyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl... 14 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Pol polyprotein inhibitor AC1LACBC family 2 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor (2R,3R)... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Renin inhibitor (3S)-3-hydroxy-6-methyl-N-(2-methylbutyl)-4-[[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00345737 CHEMBL22858 Bioactive N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]-6-formamido-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]hex-4-ynamide
CFAMM00345756 CHEMBL22912 Bioactive 6-acetamido-N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]hex-4-ynamide
CFAMM00345754 CHEMBL22504 Bioactive (3S)-4-[[6-acetamido-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]hexanoyl]amino]-3-hydroxy-6-methyl-N-(2-methylbutyl)heptanamide
CFAMM00345739 CHEMBL279917 Bioactive (3S)-4-[[4-acetamido-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]butanoyl]amino]-3-hydroxy-6-methyl-N-(2-methylbutyl)heptanamide
CFAMM00345752 CHEMBL133848 Bioactive SureCN14527548

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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