CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3352
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A inhibitor Vardenafil hydrochloride family
No. of Seeds 12 No. of Other Members 1
Family Centroid CFAMM00304829 Functional Category Bioactive
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Binder Superfamily
Class Class 3789

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 12 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 3 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alph... 2 0


External ID

Functional Category

Molecule Name

CFAMM00345854 CHEMBL414842 Bioactive SureCN5530
CFAMM00345852 CHEMBL67064 Bioactive ethoxy-[2-[1-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]ethyl]phosphinic acid
CFAMM00345851 CHEMBL434135 Bioactive 3-cyclopentyl-5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00345857 CHEMBL369081 Bioactive SureCN6338540
CFAMM00345850 CHEMBL63686 Bioactive 5-[5-[4-(diethoxyphosphorylmethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00345856 CHEMBL361582 Bioactive SureCN6332326
CFAMM00345848 CHEMBL63548 Bioactive [4-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]methylphosphonic acid
CFAMM00345855 CHEMBL183343 Bioactive SureCN6332178

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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