CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3360
Family Name Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-00FIVY family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00345889 Functional Category Bioactive
Superfamily Calpain-1 catalytic subunit and Cathepsin B Binder Superfamily
Class Class 3403

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
HIV-1 protease Inhibitor Atazanavir Family 16 58
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Ximelegatran Family 8 157
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Substance-P receptor Ligand GSK424887 Family 8 184
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Transient receptor potential cation channel subfamily V member... 6 23
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
NS5B protein inhibitor AC1NQMYG family 6 12
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S... 7 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Neuropeptide Y receptor type 5 ligand SureCN3380922 family 2 6
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 9 3
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 3
Neuromedin-K receptor ligand AGN-PC-00GCXP family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00345889 CHEMBL133970 Bioactive AGN-PC-00FIVY
CFAMM00345887 CHEMBL323869 Bioactive benzyl N-[8-(hydroxyamino)-1,8-dioxo-1-(quinolin-8-ylamino)octan-2-yl]carbamate
CFAMM00345886 CHEMBL134283 Bioactive AGN-PC-075LBH
CFAMM00345885 CHEMBL246390 Bioactive benzyl N-[(2S)-8-(hydroxyamino)-1,8-dioxo-1-(quinolin-6-ylamino)octan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27277 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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