CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3362
Family Name Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 1706 family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00226393 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2b Binder Superfamily
Class Class 253

Cousin Family NamesSeedsMembers
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-(5-ethyl-1,2,4... 25 61
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[3-fluoro-4-(5-ph... 10 2
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-[5-(cyclopenty... 27 2
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Adenosine receptor A2b and Adenosine receptor A1 ligand (8Z)-8... 3 33
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Muscarinic acetylcholine receptor M1 and Nuclear factor NF-kap... 1 12
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Adenosine receptor A1 and Adenosine receptor A2b ligand N-[2-[... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00345902 CHEMBL133982 Bioactive 3-(4-amino-3-iodophenyl)-N-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethyl]propanamide
CFAMM00345901 CHEMBL201022 Bioactive 8-[4-[2-(4-iodophenyl)-2-oxoethoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
CFAMM00345900 CHEMBL592891 Bioactive N-(4-acetylphenyl)-2-[4-(7-methyl-2,6-dioxo-1,3-dipropylpurin-8-yl)phenoxy]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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