CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3375
Family Name Cathepsin B and Cathepsin L1 inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-2-[(2,4-difluorobenzoyl)amino]-3-(3-methylphenyl)propanoyl]amino]ethoxy]methyl]benzoic acid family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00314238 Functional Category Bioactive
Superfamily Cathepsin B and Cathepsin L1 Binder Superfamily 3
Class Class 3206

Cousin Family NamesSeedsMembers
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 F... 6 8
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphe... 6 8
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 1 4
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[(... 18 17
Dipeptidyl peptidase 4 inhibitor 3-[2-[(4R,5R)-5-amino-2-oxo-4... 1 4
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Cathepsin B and Cathepsin L1 inhibitor 5-[[(2R)-2-[[(2S)-2-ani... 1 0
Cathepsin B and Cathepsin L1 inhibitor SureCN14345745 family 2 0
Plasmepsin-1 and Plasmepsin-2 inhibitor N-[(2S,3S)-5-[[(2S)-1-... 2 4
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphe... 1 0
Beta-lactamase inhibitor CHEMBL1326254 family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00346007 CHEMBL337090 Bioactive 3-[[(2R)-2-[[(2S)-2-benzamido-3-(3-methylphenyl)propanoyl]amino]-2-cyanoethoxy]methyl]benzoic acid
CFAMM00346006 CHEMBL138499 Bioactive 3-[[(2R)-2-[[(2S)-2-[(4-chloro-2-fluorobenzoyl)amino]-3-(3-methylphenyl)propanoyl]amino]-2-cyanoethoxy]methyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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