CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3381
Family Name Presenilin-1 and Presenilin-2 inhibitor (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-1-[2-(dimethylamino)-2-oxoethyl]-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00346035 Functional Category Bioactive
Superfamily Presenilin-2 and Presenilin-1 Binder Superfamily
Class Class 3126

Cousin Family NamesSeedsMembers
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Presenilin-1 and Presenilin-2 inhibitor (2S)-3-(3,4-difluoroph... 1 2
Gastrin/cholecystokinin type B receptor and Histamine H2 recep... 4 14


External ID

Functional Category

Molecule Name

CFAMM00346030 CHEMBL335184 Bioactive (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-2-oxo-1-(3-oxobutyl)-3H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide
CFAMM00346034 CHEMBL336071 Bioactive (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide
CFAMM00346027 CHEMBL341257 Bioactive (2S)-3-(3,4-difluorophenyl)-N-[(3S)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-2-methylpropanamide
CFAMM00346033 CHEMBL336813 Bioactive (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-1-(2-hydroxyethyl)-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide
CFAMM00346026 CHEMBL341256 Bioactive (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-1-[2-(methylamino)-2-oxoethyl]-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide
CFAMM00346035 CHEMBL134124 Bioactive (2S)-N-[(3S)-5-(1,3-benzodioxol-5-yl)-1-[2-(dimethylamino)-2-oxoethyl]-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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