CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM34
Family Name Integrin beta-2 and Intercellular adhesion molecule 1 inhibitor (2S)-2-[[5,7-dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-propan-2-ylphenyl)propanoic acid family
No. of Seeds 3 No. of Other Members 18
Family Centroid CFAMM00306168 Functional Category Bioactive
Superfamily Integrin alpha-4 and Integrin beta-7 Binder Superfamily
Class Class 2652

Cousin Family NamesSeedsMembers
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Cholecystokinin receptor type A Ligand Dexloxiglumide Family 5 59
Neuromedin-K receptor Ligand Osanetant Family 38 192
Integrin beta-1 Inhibitor R411 Family 33 44
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 5
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 7 3
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6823871 f... 9 0
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-2-[(2,6-di... 9 27
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-[2-(... 12 2
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-2-[(2,6-di... 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 11
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(4-brom... 2 0
Substance-P receptor ligand SureCN8936495 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306168 CHEMBL2048023 Bioactive (2S)-2-[[5,7-dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-propan-2-ylphenyl)propanoic acid
CFAMM00306173 CHEMBL282149 Bioactive (2R)-2-[[5-(8-azaspiro[4.5]decan-8-yl)-4-[(3,5-dichlorobenzoyl)amino]-5-oxopentanoyl]amino]-3-naphthalen-1-ylpropanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27285 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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