CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3427
Family Name Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-methoxy-6-(2-piperidin-1-ylethoxy)-2-(pyridin-4-ylmethylidene)-3H-inden-1-one family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00346484 Functional Category Bioactive with Natural Product
Superfamily Cholinesterase and Acetylcholinesterase Binder Superfamily 7
Class Class 2449

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Multidrug resistance-associated protein 1 Inhibitor Biricodar ... 6 40
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Acetylcholinesterase and Cholinesterase inhibitor 3-[(E)-3-[1-... 3 14
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Renin inhibitor SureCN7300793 family 2 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Nitric oxide synthase, inducible inhibitor 2-(2,3-dihydro-1,4-... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 1
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0
Collagenase 3 inhibitor 4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2... 1 0
NP 5-((4-chlorobenzyl)oxy)-2-(6,7-dimethoxy-1,2,3,4-tetrahydro... 3 0
ylethanone NP (z)-2-(7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoli... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00346466 CHEMBL135621 Bioactive SureCN8568222
CFAMM00346484 CHEMBL2043052 Bioactive (2Z)-5-methoxy-6-(2-piperidin-1-ylethoxy)-2-(pyridin-4-ylmethylidene)-3H-inden-1-one
CFAMM00346482 CHEMBL2043044 Bioactive (2Z)-5-methoxy-6-(2-piperidin-1-ylethoxy)-2-(pyridin-2-ylmethylidene)-3H-inden-1-one
CFAMM00346461 CHEMBL134441 Bioactive SureCN8574584

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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