CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3433
Family Name Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2-(naphthalen-1-ylsulfonylamino)pentanamide family
No. of Seeds 7 No. of Other Members 24
Family Centroid CFAMM00346578 Functional Category Bioactive with Natural Product
Superfamily Cathepsin B and Prothrombin Binder Superfamily
Class Class 3217

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Cathepsin K Inhibitor Odanacatib Family 33 84
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Disintegrin and metalloproteinase domain-containing protein 17... 7 39
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Calpain Inhibitor SJA-6017 Family 2 12
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Calpain-1 catalytic subunit inhibitor 6-chloro-2-methyl-1,1-di... 3 9
Prothrombin and Cationic trypsin inhibitor 2-[butyl-[(2S)-4-[[... 7 32
Prothrombin inhibitor SureCN7341151 family 6 7
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Prothrombin inhibitor bms-189090 family 1 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 1
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 8
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 10 1
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpipe... 10 4
Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethyl... 2 9
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 3 0
Neutrophil elastase inhibitor SureCN6619034 family 1 8
Neutrophil collagenase and Collagenase 3 inhibitor (2R)-2-[2-a... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
Cannabinoid receptor 1 ligand ZINC01044238 family 2 0
Cannabinoid receptor 1 ligand SureCN13668467 family 6 3
Aldose reductase inhibitor 4-chloro-2-(2,5-dioxoimidazolidin-4... 4 22
Calpain-1 catalytic subunit and Cathepsin B inhibitor (4S)-3-(... 1 0
Endothelin-converting enzyme 1 and Angiotensin-converting enzy... 1 0
Sodium channel protein type 9 subunit alpha ligand (1S,2S)-2-N... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor [(3R,5S)... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00346567 CHEMBL334443 Bioactive (2S)-3-methyl-2-(naphthalen-1-ylsulfonylamino)-N-[(2S)-1-oxopropan-2-yl]pentanamide
CFAMM00346580 CHEMBL168909 Bioactive (2S)-3-methyl-N-[(2R)-4-methyl-1-oxopentan-2-yl]-2-(naphthalen-2-ylsulfonylamino)butanamide
CFAMM00346573 CHEMBL336591 Bioactive (2S)-3-methyl-2-(naphthalen-1-ylsulfonylamino)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]pentanamide
CFAMM00346572 CHEMBL1923954 Bioactive (2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2-(naphthalen-2-ylsulfonylamino)butanamide
CFAMM00346565 CHEMBL341197 Bioactive (2S)-3-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]-2-(naphthalen-1-ylsulfonylamino)pentanamide
CFAMM00346578 CHEMBL134494 Bioactive (2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2-(naphthalen-1-ylsulfonylamino)pentanamide
CFAMM00346583 CHEMBL8605 Bioactive 1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-2H-1$l^{6},2-benzothiazine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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