CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3447
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-benzodioxol-5-yl)-2-(5-phenylfuran-2-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one family
No. of Seeds 21 No. of Other Members 11
Family Centroid CFAMM00346789 Functional Category Bioactive with Natural Product
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily 2
Class Class 97

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 3 7
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 9 13
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00346787 CHEMBL344152 Bioactive SureCN6408884
CFAMM00346763 CHEMBL344431 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-[4-(hydroxymethyl)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346778 CHEMBL334903 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-[4-(4-methylpiperazine-1-carbonyl)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346786 CHEMBL337782 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-(4-methylphenyl)furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346762 CHEMBL142030 Bioactive SureCN6407021
CFAMM00346769 CHEMBL337804 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-(furan-2-yl)furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346768 CHEMBL343596 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-[3-(hydroxymethyl)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346774 CHEMBL139785 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(5-pyridin-3-ylfuran-2-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346790 CHEMBL424280 Bioactive SureCN6407299
CFAMM00346767 CHEMBL423177 Bioactive SureCN6407804
CFAMM00346782 CHEMBL138511 Bioactive SureCN6409611
CFAMM00346754 CHEMBL337560 Bioactive 4-[5-[3-(1,3-benzodioxol-5-yl)-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carbonyl]furan-2-yl]benzonitrile
CFAMM00346773 CHEMBL335784 Bioactive SureCN6408989
CFAMM00346789 CHEMBL336921 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(5-phenylfuran-2-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346781 CHEMBL422100 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-(3-nitrophenyl)furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346751 CHEMBL343345 Bioactive 4-[5-[3-(1,3-benzodioxol-5-yl)-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carbonyl]furan-2-yl]benzaldehyde
CFAMM00346788 CHEMBL136521 Bioactive 4-[5-[3-(1,3-benzodioxol-5-yl)-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carbonyl]furan-2-yl]benzoic acid
CFAMM00346764 CHEMBL342159 Bioactive N-[4-[5-[3-(1,3-benzodioxol-5-yl)-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carbonyl]furan-2-yl]phenyl]methanesulfonamide
CFAMM00346780 CHEMBL342404 Bioactive SureCN6409766
CFAMM00346748 CHEMBL138949 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(5-pyridin-4-ylfuran-2-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00346771 CHEMBL335090 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[5-[4-(dimethylamino)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27751 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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