CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3466
Family Name D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand SureCN9089527 family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00180977 Functional Category Bioactive
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
SB1518 family 7 103
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Deoxycytidine kinase inhibitor AGN-PC-07Z9GO family 10 2
Deoxycytidine kinase inhibitor 2-[1-[6-(2-chlorophenoxy)pyrimi... 2 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 2-[[4-amin... 10 9
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 2
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 2 5
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00346880 CHEMBL329207 Bioactive N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyrimidin-4-ylpropane-1,3-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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