CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM34686
Family Name Major prion protein and Microtubule-associated protein tau inhibitor N-(4-ethoxyphenyl)-3-hydroxy-2-naphthamide family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00503285 Functional Category Bioactive with Natural Product
Superfamily 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor ONO-3805 Superfamily
Class Class 2482

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Transient receptor potential cation channel subfamily V member... 2 29
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Estradiol 17-beta-dehydrogenase 1 Inhibitor 2-hydroxy-n,6-bis(... 2 7
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Adenosine receptor A2a Ligand 1-amino-4-methoxyanthracene-9,10... 1 7
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-02INEQ... 6 6
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Prostaglandin D2 receptor 2 ligand 2-[4-methoxy-3-[2-[[(1S)-1-... 5 28
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Nucleotide-binding oligomerization domain-containing protein 1... 1 2
Estradiol 17-beta-dehydrogenase 2 and Estradiol 17-beta-dehydr... 1 2
Inosine-5'-monophosphate dehydrogenase 2 and Inosine-5'-monoph... 1 14
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
ATP-sensitive inward rectifier potassium channel 11 ligand AGN... 2 0
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
NP N-(4-(7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepine... 2 1
N-(4-hydroxyphenyl)-7,8-dimethoxy-1-oxoisothiochromene-3-carbo... 1 0
Putative NP ZINC17112928 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00503285 CHEMBL1388703 Bioactive N-(4-ethoxyphenyl)-3-hydroxy-2-naphthamide
CFAMM00503277 CHEMBL62295 Bioactive AC1LA4RN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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