CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM347
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand AGN-PC-00BUKD family
No. of Seeds 8 No. of Other Members 2
Family Centroid CFAMM00285173 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-aminobutyric acid receptor subunit gamma-2 Binder Superfamily 2
Class Class 1377

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Alprazolam Family 4 35
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A3 ligand SureCN6627522 family 3 2
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310609 CHEMBL1079300 Bioactive SureCN2431006
CFAMM00310608 CHEMBL1078368 Bioactive AGN-PC-02MCTZ
CFAMM00310606 CHEMBL1078959 Bioactive AGN-PC-00BJSR
CFAMM00310605 CHEMBL1078958 Bioactive SureCN4592960
CFAMM00310611 CHEMBL1077416 Bioactive AGN-PC-00D0MF
CFAMM00310610 CHEMBL1079301 Bioactive AGN-PC-07ZAYP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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