CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3478
Family Name Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[[4-[[(2,4-diaminoquinazolin-6-yl)-prop-2-enylamino]methyl]benzoyl]amino]pentanedioic acid family
No. of Seeds 10 No. of Other Members 5
Family Centroid CFAMM00347004 Functional Category Bioactive
Superfamily BIBT986 Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pe... 4 23
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Endothelin B receptor Ligand IRL-2500 Family 34 87
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Thymidylate synthase inhibitor AC1LABAB family 14 3
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Dihydrofolate reductase and Trifunctional purine biosynthetic ... 1 6
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Folate receptor alpha and Trifunctional purine biosynthetic pr... 9 1
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 1 7
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)pipe... 17 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Beta-secretase 1 inhibitor 3-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(... 1 0
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00347002 CHEMBL141648 Bioactive 2-[[4-[[(2,4-diaminoquinazolin-6-yl)-prop-2-ynylamino]methyl]benzoyl]amino]pentanedioic acid
CFAMM00347008 CHEMBL162476 Bioactive 2-[[4-[(2,4-diaminoquinazolin-5-yl)methylamino]benzoyl]amino]pentanedioic acid
CFAMM00347006 CHEMBL134817 Bioactive AGN-PC-075LPK
CFAMM00347004 CHEMBL141576 Bioactive 2-[[4-[[(2,4-diaminoquinazolin-6-yl)-prop-2-enylamino]methyl]benzoyl]amino]pentanedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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