CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM348
Family Name Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC-01MMUR family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00310616 Functional Category Bioactive with Natural Product
Superfamily cAMP and Glucokinase Binder Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-00KCTP family 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Sodium/glucose cotransporter 2 inhibitor AGN-PC-0A9TPG family 2 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310616 CHEMBL340262 Bioactive AGN-PC-01MMUR
CFAMM00310614 CHEMBL1077405 Bioactive AGN-PC-00KCTK
CFAMM00310620 CHEMBL126061 Bioactive AGN-PC-01MMSV

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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